Quadruple DNA helix discovered in human cells








































Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.













Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.












The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.












Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.












"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.











Tagged with antibodies













Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.












This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.












"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.












"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.












Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.












Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Auction for Singapore's F&N begins






SINGAPORE: A rare auction for a listed Singaporean company opened on Monday with Thai and Indonesian tycoons facing off to take over diversified conglomerate Fraser and Neave (F&N).

The auction was called by a stock-market watchdog to resolve a protracted battle for F&N after it sold off its most prized asset, Tiger Beer maker Asia Pacific Breweries, to Dutch giant Heineken in September.

At stake are F&N's property, beverages and publishing operations.

A spokesman for the Securities Industry Council (SIC), which called for the auction, said the process officially opened on Monday after Thai billionaire Charoen Sirivadhanabhakdi made a fresh pre-auction bid over the weekend.

Charoen's TCC Assets said Saturday it was increasing its offer for F&N shares it does not own from S$8.88 ($7.24) a share to S$9.55.

The total S$13.75 billion offer trumped the S$13.1 billion, or S$9.08 per share, bid tabled by property firm Overseas Union Enterprise (OUE) in mid-November, but it was still lower than F&N's closing price last week.

The stock surged 1.25 percent, or 12 cents, to S$9.70 by 0130 GMT on Monday.

The revised bid leaves "the Thais in the driving seat this morning", IG Markets said in a report.

"The drawn-out sparring match for the prized asset of Fraser & Neave has reached the final round with the Thais delivering what could be the knockout punch," the report added.

OUE is controlled by Indonesia's Lippo Group, whose founder is Indonesian tycoon Mochtar Riady. His son Stephen is OUE's executive chairman.

Under the auction rules set by SIC, a daily bidding process will take place starting Monday until one party gives up.

F&N shareholders had reacted coolly to the original bids after an adviser gave a much higher valuation than those tabled by TCC Assets and OUE.

- AFP/al



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Stan 'The Man' Musial dies




Photo portrait of Stan Musial in the 1960s.




STORY HIGHLIGHTS


  • Musial played 22 years in the Major League, all with the St. Louis Cardinals

  • He retired in 1963 as, statistically, one of the best hitters in baseball history

  • He died Saturday evening of natural causes, his grandson says

  • Baseball commissioner, players, fans recall Musial as a great athlete and man




(CNN) -- He was simply "The Man."


Stanley Frank Musial made a name for himself as one of baseball's best hitters of all time on the field, as well as one of its greatest, most dignified ambassadors off it.


And now "Stan the Man" is gone. Musial died at his Ladue, Missouri, home surrounded by family, the Cardinals said in a statement. According to a post on his Twitter page, which is maintained by his grandson Brian Musial Schwarze, Musial died at 5:45 p.m. (6:45 p.m. ET) Saturday of natural causes.


He was 92.


"We have lost the most beloved member of the Cardinals family," said William DeWitt Jr., the club's chairman. "Stan Musial was the greatest player in Cardinals history and one of the best players in the history of baseball."


The Pennsylvania-born Musial transitioned from a lackluster pitcher to a stellar slugging outfielder, according to his biography on the National Baseball Hall of Fame's website.


The left-hander had a batting average above .300 17 times during his 22-year career -- all played with St. Louis -- and earned three National League Most Valuable Player awards as well as three World Series titles. The only blip came in 1945, in the thick of World War II, when he left baseball to join the U.S. Navy.




Stan Musial waves to fans during the 2012 National League Championship Series.



After the 1963 season, Musial retired with a .331 career batting average and as the National League's career leader in RBI, games played, runs scored, hits and doubles. He has since been surpassed in some of those categories, but he still ranks fourth in baseball history in total hits, behind only Pete Rose, Ty Cobb and Hank Aaron.


Hall of Fame manager Earl Weaver dead


He also stood out for his grace and sportsmanship -- having never been ejected once by an umpire. In his retirement ceremony, then-Major League Commissioner Ford Frick referred to Musial as "baseball's perfect warrior, baseball's perfect knight."


In 1969, Musial was elected on his first try into the Hall of Fame, calling it "the greatest honor of the many that have been bestowed upon me."


During and after his playing career, Musial developed a special relationship with the St. Louis fan base, who knew him simply as "Stan the Man."


A bronze statue of him stands outside Busch Stadium, which is located in Musial Plaza along Stan Musial Drive.


He continued with the organization for more than 25 years after his playing days ended, serving as vice president and general manager.


And Musial was active in the community, contributing to causes such as the USO, the Senior Olympics, the Boy Scouts and Covenant House.









People we lost in 2013











HIDE CAPTION









"I have no hesitation to say that St. Louis is a great place in which to live and work," he said in his Hall of Fame induction speech. "We love St. Louis."


His fans returned the favor, revering him for his play as well as his character and commitment to the area.


"Cardinal Nation will never be the same. Rest in peace Stan 'The Man' Musial, the best Cardinal there ever was," wrote one woman, by the name of Elise, on Twitter.


Musial also stood tall outside eastern Missouri. He served between 1964 and 1967 as chairman of the President's Council on Physical Fitness and Sports.


In 2011, President Barack Obama bestowed upon him the Presidential Medal of Freedom, the nation's highest civilian honor.


"Stan matched his hustle with humility," Obama said then. "Stan remains, to this day, an icon, untarnished; a beloved pillar of the community; a gentleman you'd want your kids to emulate."


Lillian, Musial's wife of 71 years, died last May -- a longlasting marriage that some people, online, called as admirable as anything that happened on the diamond.


Stan Musial's passing spurred an outpouring of condolences and praise. Commissioner Bud Selig described him as "a Hall of Famer in every sense" and "a true gentleman," former pitcher Curt Schilling called his life "a clinic in respect, integrity and honor," and current Cardinal Matt Holliday said it was "an honor to the same uniform."


The messages from fans were no less heartfelt.


Wrote Jason Lukehart, on Twitter: "In a week that's shown the dangers deifying athletes, Stan Musial's death reminds me that once in a great while, there's a man worthy of it."







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MLK's "content of character" quote inspires debate

"I have a dream that my four little children will one day live in a nation where they will not be judged by the color of their skin but by the content of their character."

This sentence spoken by the Rev. Martin Luther King Jr. has been quoted countless times as expressing one of America's bedrock values, its language almost sounding like a constitutional amendment on equality.




20 Photos


Martin Luther King Jr.






Play Video


Martin Luther King III talks his father's legacy






Play Video


King, Civil Rights Act remembered



Yet today, 50 years after King shared this vision during his most famous speech, there is considerable disagreement over what it means.

The quote is used to support opposing views on politics, affirmative action and programs intended to help the disadvantaged. Just as the words of the nation's founders are parsed for modern meanings on guns and abortion, so are King's words used in debates over the proper place of race in America.

As we mark the King holiday, what might he ask of us in a time when both the president and a disproportionate number of people in poverty are black? Would King have wanted us to completely ignore race in a "color-blind" society? To consider race as one of many factors about a person? And how do we discern character?

For at least two of King's children, the future envisioned by the father has yet to arrive.

"I don't think we can ignore race," says Martin Luther King III.

"What my father is asking is to create the climate where every American can realize his or her dreams," he says. "Now what does that mean when you have 50 million people living in poverty?"

Bernice King doubts her father would seek to ignore differences.

"When he talked about the beloved community, he talked about everyone bringing their gifts, their talents, their cultural experiences," she says. "We live in a society where we may have differences, of course, but we learn to celebrate these differences."

The meaning of King's monumental quote is more complex today than in 1963 because "the unconscious signals have changed," says the historian Taylor Branch, author of the acclaimed trilogy "America in the King Years."

Fifty years ago, bigotry was widely accepted. Today, Branch says, even though prejudice is widely denounced, many people unconsciously pre-judge others.

"Unfortunately race in American history has been one area in which Americans kid themselves and pretend to be fair-minded when they really are not," says Branch, whose new book is "The King Years: Historic Moments in the Civil Rights Movement."

Branch believes that today, King would ask people of all backgrounds - not just whites - to deepen their patriotism by leaving their comfort zones, reaching across barriers and learning about different people.

"To remember that we all have to stretch ourselves to build the ties that bind a democracy, which really is the source of our strength," Branch says.

Bernice King says her father is asking us "to get to a place - we're obviously not there - but to get to a place where the first thing that we utilize as a measurement is not someone's external designation, but it really is trying to look beyond that into the substance of a person in making certain decisions, to rid ourselves of those kinds of prejudices and biases that we often bring to decisions that we make."

That takes a lot of "psychological work," she says, adding, "He's really challenging us."

For many conservatives, the modern meaning of King's quote is clear: Special consideration for one racial or ethnic group is a violation of the dream.

The quote is like the Declaration of Independence, says Roger Clegg, president of the Center for Equal Opportunity, a conservative think tank that studies race and ethnicity. In years past, he says, America may have needed to grow into the words, but today they must be obeyed to the letter.

"The Declaration of Independence says all men are created equal," Clegg says. "Nobody thinks it doesn't really mean what it says because Thomas Jefferson owned slaves. King gave a brilliant and moving quotation, and I think it says we should not be treating people differently on the basis of skin color."

Many others agree. King's quote has become a staple of conservative belief that "judged by the color of their skin" includes things such as unique appeals to certain voter groups, reserving government contracts for Hispanic-owned businesses, seeking more non-white corporate executives, or admitting black students to college with lower test scores.

In the latest issue of the Weekly Standard magazine, the quote appears in the lead of a book review titled "The Price Was High: Affirmative Action and the Betrayal of a Colorblind Society."

Considering race as a factor in affirmative action keeps the wounds of slavery and Jim Crow "sore and festering. It encourages beneficiaries to rely on ethnicity rather than self-improvement to get ahead," wrote the author, George Leef.

Last week, the RightWingNews.com blog included "The idea that everyone should be judged by the content of their character, not the color of their skin" in a list of "25 People, Places and Things Liberals Love to Hate."

"Conservatives feel they have embraced that quote completely. They are the embodiment of that quote but get no credit for doing it," says the author of the article, John Hawkins. "Liberals like the idea of the quote because it's the most famous thing Martin Luther King said, but they left the principles behind the quote behind a long time ago."


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Obamas Share the Love, Even for Michelle's Bangs


Jan 20, 2013 10:49pm







ap obamas 130120 wblog Obama Calls First Ladys Bangs Most Significant Event of Inaugural Weekend

(Charles Dharapak/AP Photo)


President Obama used the first public remarks of his second term to address what he called the “most significant” event of this weekend: his wife’s much-talked-about new haircut.


“I love her bangs,” Obama told supporters at an inaugural reception at the National Building Museum. “She looks good. She always looks good.”



First lady Michelle Obama, wearing a black sequined cocktail dress and showcasing her new hairdo, also heaped compliments on her husband.


“Let me tell you, it has just been a true thrill to watch this handsome, charming individual grow into the man and the president that he is,” she said, as she reached out to playfully touch the president’s face, sparking laughter from the crowd.


Praising his compassion and courage, the first lady introduced the president as the “love of her life.”


Obama, who was sworn in for a second term in a small White House ceremony earlier today, kept his remarks short, noting he has another big speech to deliver Monday.


“There are a limited amount of good lines and you don’t want to use them all up tonight,” he joked.


Because the Constitutionally mandated date for the inauguration, Jan. 20, fell on a Sunday this year, the traditional, public ceremony was delayed until Monday.


Saving the best for his official inaugural address, the president instead dedicated the bulk of his remarks to thanking supporters for their hard work and dedication to getting him re-elected.


“You understood this was not just about a candidate; it was not just about Joe Biden or Barack Obama. This was about us, who we are as a nation, what values we cherish, how hard we’re willing to fight to make sure that those values live not just for today but for future generations,” he said.


“All of you here understood and were committed to the basic notion that when we put our shoulders to the wheel of history, it moves… It moves forward. And that’s part of what we celebrate when we come together for inauguration,” he said.



SHOWS: World News







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Earth may be crashing through dark matter walls



































Earth is constantly crashing through huge walls of dark matter, and we already have the tools to detect them. That's the conclusion of physicists who say the universe may be filled with a patchwork quilt of force fields created shortly after the big bang.












Observations of how mass clumps in space suggest that about 86 per cent of all matter is invisible dark matter, which interacts with ordinary matter mainly through gravity. The most popular theory is that dark matter is made of weakly interacting massive particles.











WIMPs should also interact with ordinary matter via the weak nuclear force, and their presence should have slight but measurable effects. However, years of searches for WIMPs have been coming up empty.













"So far nothing is found, and I feel like it's time to broaden the scope of our search," says Maxim Pospelov of the University of Victoria in Canada. "What we propose is to look for some other signatures."











Bubbly cosmos













Pospelov and colleagues have been examining a theory that at least some of the universe's dark matter is tied up in structures called domain walls, akin to the boundaries between tightly packed bubbles. The idea is that the hot early universe was full of an exotic force field that varied randomly. As the universe expanded and cooled, the field froze, leaving a patchwork of domains, each with its own distinct value for the field.












Having different fields sit next to each other requires energy to be stored within the domain walls. Mass and energy are interchangeable, so on a large scale a network of domain walls can look like concentrations of mass – that is, like dark matter, says Pospelov.












If the grid of domain walls is packed tightly enough – say, if the width of the domains is several hundred times the distance between Earth and the sun – Earth should pass through a domain wall once every few years. "As a human, you wouldn't feel a thing," says Pospelov. "You will go through the wall without noticing." But magnetometers – devices that, as the name suggests, measure magnetic fields – could detect the walls, say Pospelov and colleagues in a new study. Although the field inside a domain would not affect a magnetometer, the device would sense the change when Earth passes through a domain wall.












Dark matter walls have not been detected yet because anyone using a single magnetometer would find the readings swamped by noise, Pospelov says. "You'd never be able to say if it's because the Earth went through a bizarre magnetic field or if a grad student dropped their iPhone or something," he says.











Network needed













Finding the walls will require a network of at least five detectors spread around the world, Pospelov suggests. Colleagues in Poland and California have already built one magnetometer each and have shown that they are sensitive enough for the scheme to work.












Domain walls wouldn't account for all the dark matter in the universe, but they could explain why finding particles of the stuff has been such a challenge, says Pospelov.












If domain walls are found, the news might come as a relief to physicists still waiting for WIMPs to show up. Earlier this month, for instance, a team working with a detector in Russia that has been running for more than 24 years announced that they have yet to see any sign of these dark matter candidates.












Douglas Finkbeiner of the Harvard-Smithsonian Center for Astrophysics, who was not involved in Pospelov's study, isn't yet convinced that dark matter walls exist. But he is glad that physicists are keeping an open mind about alternatives to WIMPs.












"We've looked for WIMP dark matter in so many ways," he says. "At some point you have to ask, are we totally on the wrong track?"












Journal reference: Physical Review Letters, DOI: 10.1103/PhysRevLett.110.021803


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Hundreds stranded as Scoot flights delayed






SINGAPORE: Hundreds of passengers were stranded after their flights on the budget airline Scoot were delayed.

Callers to the MediaCorp News hotline said flights from Singapore to Bangkok in Thailand and back, and flights from Singapore to Tianjin in China were affected.

One caller reported that more than 300 passengers were stuck at Changi Airport after their scheduled flight TZ88 to Tianjin did not take off.

A Scoot spokesperson said the issue arose when due to technical reasons, the airline was not able to accommodate 23 people booked on the Bangkok bound flight.

After unsuccessfully seeking volunteers, the last 23 passengers to check in were told that they could not board and would be given tickets on the next day's flight plus compensation - in accordance with the terms and conditions they accepted upon purchase of their tickets.

The spokesperson said regrettably the 23 passengers would not accept the offer.

A large group of their friends who were already in the boarding area then became disruptive and would not let the flight board.

Eventually, after a lengthy delay, 23 other passengers agreed to travel at a later date and the aircraft left for Bangkok.

The aircraft deployed to Bangkok, upon its return to Singapore, subsequently operates to Tianjin.

The spokesperson added that because of the delayed departure to Bangkok, its return to Singapore was also delayed and, hence, the Tianjin flight too.

Some passengers who had checked in for the Tianjin flight returned home, while others stayed in the airport and have been provided meal vouchers and refreshments.

Scoot said it sincerely regrets the disruption.

- CNA/ck



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Historic D.C., hidden in plain sight














Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know








STORY HIGHLIGHTS


  • Washington, D.C. holds a lot of nearly hidden history

  • A tennis court occupies the site of the execution of Lincoln assassination conspirators

  • A present-day parking garage once hosted a historic Beatles show




Washington (CNN) -- Ordinarily, I'm not a fan of vandalism.


But years ago I spotted some graffiti in Washington that struck a chord. Someone had spray painted the symbol for anarchy -- a circled "A" -- on a Chinatown grocery store.


And I wondered: Did they know?


Did they know that that building, a century earlier, had been Mary Surratt's boarding house? Did they know that conspirators had gathered there to plot the kidnapping and assassination of an American president? Did they know that the site had played a role in the biggest act of anarchy in this country's history?


Was the graffiti just accidentally appropriate? Or could punks with paint be profound?


I don't know the answer, of course. But I know that this city is teeming with people who, like me, relish its hidden history.


Washington is a town of majestic monuments and memorials. And those are worth visiting. But if you limit your sightseeing to the obvious -- if you ignore the obscure -- you'll miss the good stuff.


That is what I had in mind when I asked historians and history buffs to show me places -- off the beaten path -- that have stirred their love of history and this great town.


WASHINGTON COLISEUM: "I Saw Them Standing There"


Four boys, in dire need of haircuts, come to town, looking to conquer it.


The British tried it once before, in 1814. Burned the city. It left a bad taste in everyone's mouth.


But this time, they try soft diplomacy. A little twist and shout. A little ditty about wanting to hold your hand.


And it works.


Improbable as it sounds, it happened in a barrel-shaped architectural ruin just north of the Capitol on 3rd Street NE.


Shortly after 8:30 p.m. on Feb. 11, 1964 -- two days after appearing on "The Ed Sullivan Show" -- the Beatles took the stage in Washington Coliseum. It was the Beatles' very first stage concert in the United States.


Critics later say the concert is as singular moment in rock history -- a moment when the early Beatles seemed even more joyous than their shrieking teen-age fans.


Richard Layman, who fought to preserve the Coliseum, cherishes this place for many reasons. Built in 1940 and 1941, the building served as an ice rink, sports arena, worship hall, trash transfer station and parking garage. Nation of Islam leaders Malcolm X and Elijah Muhammed spoke here. It hosted numerous professional sports teams, and was home to the Ice Capades.


For Beatle devotees, this is a shrine.


They still have ticket stubs, and remember whether they paid $2, $3 or $4. They gush about how Paul smiled at them.


An age of innocence? Not exactly. The Russians threatened us from outer space. The pains of segregation and integration were rocking the country. And, just three months earlier, an assassin felled the leader of the free world.


But for about 35 minutes on a cold February night in 1964, four boys from Liverpool entered a converted ice rink and warmed a generation's heart.


COURTROOM DRAMA: Last act of the Civil War


The man, a tavern owner, took the witness stand.


"I was acquainted with John Wilkes Booth," he said. "Booth came into my restaurant [adjoining Ford's Theater] on the evening of the 14th of April."


Booth "walked up to the bar, and called for some whiskey, which I gave him; he called for some water, which I also gave him; he placed the money on the counter and went out. I saw him go out of the bar alone, as near as I can judge, from eight to ten minutes before I heard the cry that the President was assassinated."


Peter Taltavul spoke those words, in this room, just one month after Lincoln died.


By then, authorities had already tracked down Booth, cornered him, and killed him. And they had rounded up eight people who they believe had assisted him.


They convened a military commission to conduct the trial in the third floor of what was then a federal penitentiary. The co-conspirators, they reasoned, were not "civilians," but were "enemy belligerents." The nation was seeking justice and vengeance, and it would come swiftly.


On July 6, 1865 -- less than three months after the assassination -- the commission found all eight conspirators guilty. It sentenced four to hang, and four to prison terms. The condemned were hanged the next day.


A year later, the Supreme Court would rule that a defendant could not be tried by military commission when civilian courts were functioning. But it was too late.


The penitentiary is now closed and largely demolished. The land is part of Fort McNair at the southernmost point of Washington.


Visitors -- mostly lawyers and Civil War buffs -- are frequently overwhelmed when they enter the room, said Susan Lemke, a special collections librarian who has accumulated artifacts related to the trial. "There's no substitution for actually witnessing or being in the middle of a historic site like that," she said.


THE GALLOWS: Where generals "serve," conspirators hanged


Michael Kauffman is struck by the incongruity of it all.


On the edge of a Fort McNair tennis court, where generals now casually toss their gym bags, Abraham Lincoln's death was avenged.


Here in this spot, near the penitentiary room where the sentences were handed down, on a miserably hot day in July 1865, Union Army Capt. Christian Rath raised his hands and clapped three times. On the third clap, soldiers knocked supports out from under a gallows, and four prisoners fell. Their bodies jerked violently at the ends of their ropes. The prisoner in the dress appeared to die instantly. But one of her three accused accomplices writhed for five minutes before surrendering his ghost.


"I am one of those people who think that if you really want to understand history, you have to go to where it happened," says Kauffman, an expert on the Lincoln assassination.


So Kauffman leads me to this empty tennis court. It is drizzly and cold, and there is little here to evince the images and emotions of that hot July day. The penitentiary's tall wall has been demolished, and a building prominent in photos of the hanging has been altered almost beyond recognition.


Almost.


Kauffman shows me the place where the wall met the building. And in my mind's eye, the gallows fall into place.


"There's this strange sort of excitement that you get when you've read about something, and you visualize it, and you think you know all about it. And then all of a sudden you go there and it's right in front of you. It surrounds you. And it's always somehow different from what you had imagined," Kauffman said.


Different, to be sure. But more real than ever.


CHADWICKS: Where the U.S. was shaken, and stirred


It is known as "The Big Dump."


On June 16, 1985, CIA officer Aldrich Ames walked into Chadwicks, a Georgetown pub, with two shopping bags full of classified information and, over lunch, gave them to a Soviet diplomat.


"In those bags was every piece of paper he could get his hands on that revealed almost all of our operations in the Soviet Union," said Peter Earnest, a former CIA official who is now executive director of the International Spy Museum in D.C.


Five to seven pounds of secrets.


The enormity of the breach became known only after the Soviet Union began rounding up some of the United States' most valuable assets in Russia. At least 10 were executed.


The CIA launched a hunt for a possible mole. It compiled a list of 190 CIA officers with access to relevant classified information, and culled it to 28. And in 1994 -- nine years after the Big Dump -- Ames and his wife were arrested.


Earnest says he doesn't "romanticize" the Chadwick's site, but says "the repercussions of what he did ripple through the government today -- the need to have more polygraphs, the concerns about our records ... the nature of the questions asked."


It's also a waypoint in the Spy Museum's bus tour, which notes the role that Ames' "high-maintenance" wife Rosario played in his betrayal of his country.


Tour guides note that after Ames was arrested, FBI agents who eavesdropped on their conversations made an astonishing comment: They were so disgusted with Rosario's constant badgering about money, her criticisms of Ames and her treatment of their son that although they could never forgive Ames for spying, they said, they would have understood if he had killed his wife.


ALEXANDRIA SLAVE PEN: From slave to freeman


"PRICE, BIRCH & CO," the sign read. "DEALERS IN SLAVES."


The sign is long gone, but the building, known as the "Alexandria Slave Pen," still stands in Alexandria, Virginia, just across the river from Washington.


"I often tell my students, 'You've gone into towns where you just see row after row of car dealerships. Duke Street was that -- but slave dealerships,'" says Chandra Manning, associate professor of history at Georgetown University.


In 1861, the slave trade was thriving when Virginia seceded from the union. But on May 24 of that year, the Union Army's First Michigan Infantry marched into town, and one of the first things it did was liberate the slaves.


Ironically, the slave pen became a refuge for runaway and freed slaves seeking the protection of the Union Army.


Today, 1315 Duke Street is home to the Alexandria branch of the National Urban League, a civil rights organization. A historical marker stands outside, and there's a small museum in the basement.


But Manning believes most passersby have no idea about the building's horrific past.


Most, but not all.


"If you're walking with me," Manning says, "you have no choice but to know what happened here."


THE FORGOTTEN CRASH: History lost and relived


On a fog-shrouded evening on the penultimate day of 1906, a dead-heading train roared down this stretch of tracks near Washington's Catholic University, coming upon a slower passenger train heading the same direction on the same track. There was no time to stop.


Railroad workers have an antiseptic -- but descriptive -- word for what happened next: Telescoping.


The massive steel engine of the speeding train plowed through the flimsy wooden passenger car of the slower train, killing and dismembering its occupants. It plowed through the next car as well, and the one after that. When the trains came to a stop, cinders and soot from the locomotive's fire box rained down on the splintered wooden planks, clothing, Christmas gifts and human remains. Fifty-three people died, and more than 70 were injured.


Today, the "Terra Cotta" crash is all but lost to history. Every day, thousands pass the site, where there isn't even a hint of the horror that happened.


But Richard Schaffer, a D.C. firefighter who spent 10 years researching the crash, says Terra Cotta nonetheless changed railroading. It hastened the conversion of passenger cars from wood to steel and led to improvements in railroad signaling. That happened, he says, because the crash happened on "the route to Congress."


There's a saying, sometimes attributed to Mark Twain: "History doesn't repeat itself, but it does rhyme."


History rhymed in June 2009 -- nearly 103 years later -- when a D.C. Metro subway train plowed into another subway train. The cars telescoped, killing nine and injuring dozens.


"The irony was it was practically the same location and practically all the same problems, human error, signaling problems, construction quality of the trains," Schaffer said.


Both wrecks deserve to be remembered.


"If you forget what's happened before you," Schaffer says, "you don't have a foundation to live upon."


CONGRESSIONAL CEMETERY: The last hurrah


Can there be any doubt what happens here when the sun goes down?


Can there be any doubt that, when the gates close and the last visitor leaves this historic burial ground, band leader John Philip Sousa reaches for his baton, Civil War photographer Mathew Brady tweaks his camera, and J. Edgar Hoover tries to keep the whole mess under control?


This is Congressional Cemetery, where Washington's political and social establishment rests in eternal peace. In the 1800s, its heyday, this was the site of grand funeral processions. Tens of thousands of Washingtonians would gather to watch soldiers carry fallen leaders down a slate path to graves or crypts.


"I'm sure there are quite a few secrets buried here," says Abby Johnson.


Abby and her husband Ronald, professors of literature and history respectively at Georgetown University, take me to the "Public Vault," a crypt the size of a one-car garage. Built in the 1830s, the vault was used to store the bodies of public officials until the ground thawed, or until they were moved to other locations.


You need a skeleton key, of course, to get inside.


Dolly Madison slept here. As did three presidents: William Henry Harrison (1841), John Quincy Adams (1848), and Zachary Taylor (1850). Harrison's three-month stay was three times longer than his presidential term. All the presidents' bodies have since been moved to their home states.


Today, Congressional Cemetery, which boasts of being "in the shadow" of the U.S. Capitol, is overshadowed by a more prominent cemetery -- Arlington. But the Johnsons are devoted to keeping Congressional's memory alive. At least as long as they are alive. And then maybe, just maybe, beyond.







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Failed assassination attempt in Bulgaria - caught on tape

January 19, 2013 12:29 PM

In a failed assassination attempt on the leader of Bulgaria's ethnic Turkish party, Ahmed Dogan, a man is seen jumping out of the audience and onto the stage where Dogan is speaking. He then points the gun at Dogan's head and the gun reportedly misfires. The attacker is then tackled and beaten by security guards.

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Algeria Hostage Crisis Over, One American Dead













After the Algerian military's final assault on terrorists holding hostages at a gas complex, the four-day hostage crisis is over, but apparently with additional loss of life among the foreign hostages.


One American, Fred Buttaccio of Texas, has been confirmed dead by the U.S. State Department. Two more U.S. hostages remain unaccounted for, with growing concern among U.S. officials that they did not survive.


But another American, Mark Cobb of Corpus Christi, Texas is now confirmed as safe. Sources close to his family say Cobb, who is a senior manager of the facility, is safe and reportedly sent a text message " I'm alive."










Inside Algerian Hostage Crisis, One American Dead Watch Video









American Hostages Escape From Algeria Terrorists Watch Video





In a statement, President Obama said, "Today, the thoughts and prayers of the American people are with the families of all those who were killed and injured in the terrorist attack in Algeria. The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms. ... This attack is another reminder of the threat posed by al Qaeda and other violent extremist groups in North Africa."


According to Algerian state media, 32 militants are dead and a total of 23 hostages perished during the four-day siege of the In Amenas facility in the Sahara. The Algerian Interior Ministry also says 107 foreign nationals who worked at the facility for BP and other firms were rescued or escaped from the al Qaeda-linked terrorists who took over the BP joint venture facility on Wednesday.


The Japanese government says it fears "very grave" news, with multiple casualties among the 10 Japanese citizens working at the In Amenas gas plant.


Five British nationals and one U.K. resident are either deceased or unaccounted for in the country, according to British Foreign Minister William Hague. Hague also said that the Algerians have reported that they are still trying to clear boobytraps from the site.




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